Prefrontal And Medial Temporal Lobe Interactions In Long Term Memory Pdf

By Flavio L.
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21.05.2021 at 06:23
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prefrontal and medial temporal lobe interactions in long term memory pdf

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The role of the hippocampus in declarative memory consolidation is a matter of intense debate.

Cortical-subcortical interactions in psychiatric disease View all 11 Articles.

Prefrontal-Hippocampal Interactions in Memory and Emotion

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Much progress has been made by cognitive neuroscientists in understanding the separate roles of the medial temporal and prefrontal lobes in memory, but the way in which these regions interact in the processes of remembering has been neglected. This review provides a synthesis of evidence from human and animal neuropsychology, functional neuroimaging, neurophysiology and computational modelling, through which the functional interactions between prefrontal and medial temporal cortices can be better understood.

Critically, we corrected for the performance on the respective memory task when analyzing subsequent memory effects. Each trial consisted of an indoor or outdoor scene in which the exact configuration of four objects had to be remembered. After scanning, participants received an unexpected subsequent recognition memory LTM task, where the two previously unprobed objects were tested. Brain activity during encoding, delay phase and probe phase was analyzed based on WM and LTM performance. Results showed that successful WM performance, when corrected for LTM performance, was associated with greater activation in the inferior frontal gyrus and left fusiform gyrus during the early stage of the maintenance phase. A correct decision during the WM probe was accompanied by greater activation in a wide network, including bilateral hippocampus, right superior parietal gyrus and bilateral insula. No voxels exhibited supra-threshold activity during the encoding phase, and we did not find any differential activity for correct versus incorrect trials in the WM task when comparing LTM correct versus LTM incorrect trials.


The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information.

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Long-term memory LTM is the stage of the Atkinson—Shiffrin memory model where informative knowledge is held indefinitely. It is defined in contrast to short-term and working memory , which persist for only about 18 to 30 seconds. Long-term memory is commonly labelled as explicit memory declarative , as well as episodic memory , semantic memory , autobiographical memory , and implicit memory procedural memory. According to Miller , whose paper in popularized the theory of the "magic number seven" , short-term memory is limited to a certain number of chunks of information, while long-term memory has a limitless store. According to the dual store memory model proposed by Richard C. Atkinson and Richard Shiffrin in , memories can reside in the short-term "buffer" for a limited time while they are simultaneously strengthening their associations in long-term memory.

Prefrontal-Hippocampal Interactions in Memory and Emotion

Source data, tasks, and protocols are openly available from links below. Preprints Korkki, S. Hippocampal-cortical encoding activity predicts the precision of episodic memory. I remember it like it was yesterday: Age-related changes in the subjective experience of remembering the past. Did I imagine that?

How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex PFC , but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe MTL; including the hippocampus.

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Nikolai Axmacher, Daniel P. Schmitz, Ilona Weinreich, Christian E.

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Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval


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